Main Office, PCL
Address: Haimen Biotech and Pharmaceutical Park, Riverside New District, Haimen, Jiangsu Province, China
Tel：+86 0513 68015200
Email:infor@pharmacorelab.com
Website: www.pharmacorelab.com
Branch Office, PCL
Address: Block 6D, 780 Cailun Road, China (Shanghai) pilot free trade zone. infor@pharmacorelab.com
•Qualify your hits with biophysical characterization of the mechanism of action.
•Drive SAR to increase potency and reduce off-target and toxic effects.
•Prioritize your hits using in vivo screening tools with medium-throughput.
Cell-based activity screening
Following biochemical screening, cell-based activity testing of compounds accounts for parameters influencing the potency of compounds such as the need to cross the membrane
and physiologic levels of ATP, co-factors, and pH.
Cellular phosphorylation, methylation and deacetylation assays allow compound screening on endogenous enyzmes whereas the NanoBRETTM technology enables investigation of target engagement in the cellular setup.
In additon, cell-based activity assays are available for targeting GPCRs and ion channels for both primary and secondary screening.
Four biophysical platforms are available for characterization of the compound-target interaction on a molecular level
In vivo screening of compounds
The In Vivo Hollow Fiber Model enables an early potency evaluation in the physiological environment of a body with medium throughput.
Structure – Activity – Relationship
The partnership with our MedChem partners‘ specialists enable our clients to access medicinal chemistry expertise during the various phases of the drug discovery process. Reaction Biology has the means to test improvements of the changes in the chemical structure in regards of potency, functional effects, selectivity, pharmacodynamic/ pharmacokinetic profile, toxicity and bioavailability.
We have worked with our MedChem partners in numerous projects over the course of the last 10 years and can provide seamless interaction to drive fast SAR cycles.
